2 edition of Comparative activity of some carcinogenic hydrocarbons found in the catalog.
Comparative activity of some carcinogenic hydrocarbons
J. M. Twort
Printed in America.
|Statement||J. M. Twort and C. C. Twort.|
|Contributions||Twort, C. C.|
|The Physical Object|
|Pagination||p. 80-85 ;|
|Number of Pages||85|
Aromatic compounds are frequently carcinogenic because their physical molecular structures frequently contain five and six carbon rings. These five and six carbon rings are hydrophobic - that is, they can usually diffuse easily across hydrophobic cell membranes where they can further affect cells biologic function. Once inside cells these flat, platelike . Benzo[a]pyrenes belong to a class of compounds known as the PAHs (Polycyclic Aromatic Hydrocarbons). PAHs have a characteristic cleft called the "bay region" and are oxidized by mammalian metabolic enzymes to form carcinogens. Fig.: Oxidation o.
The carcinogenic activity exhibited by a PAH is determined by the competition between the carcinogenesis and detoxification, in which it participates. The detoxificative efficacy of each kind of the hinder carcinogenic factors has been evaluated, including the biologic factor B and three structural factors of PAH’s molecule: K, A and L. Environmental Carcinogens book. Polycyclic Aromatic Hydrocarbons. Environmental Carcinogens book. Polycyclic Aromatic Hydrocarbons. By G. Grimmer. Edition 1st Edition. First Published eBook Published 18 January Pub. location Boca Raton. Imprint CRC Press. putting special emphasis on their carcinogenic activity. The.
This chapter summarizes the findings on carcinogenicity of jet-propulsion fuel 8 (JP-8) presented in the National Research Council report Permissible Exposure Levels for Selected Military Fuel Vapors (NRC ) and reviews additional studies on JP-8 and related mixtures, some of which were completed after the report was published. The studies are summarized in Table Various spices especially garlic and onion are added in the marinade to contribute the unique flavor and taste. Some studies have shown that the addition of ingredients with an antioxidant activity (garlic, onion, lemon juice, etc.) could reduce PAH levels and other carcinogens such as heterocyclic aromatic amines (HCAs) in meat products .
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Comparative tumor-initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons, Cancer Cited by: 5.
Comparative study of the carcinogenic activities of nas and some chemical carcinogens when introduced into the buccal pouch of the Syrian hamster * I. Milievskaja and N. Kiseleva * From the Department of Epidemiology of Malignant Tumours, Institute of Experimental and Clinical Oncology, Academy of Medical Sciences of the USSR, Karširskoe Cited by: 2.
This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter. The carcinogenic activity of some new derivatives of aromatic hydrocarbons. Cancer Res., 3, 10 Gelboin, H.V.
and T'so, P.O. () Polycyclic hydrocarbons and cancer, Vol 1. Environment, Chemistry and Metabolism, Academic Press, New York.
11 Hartwell, J.L. () Survey of Compounds Which Have Been Tested for Carcinogenic by: The Carcinogenic Activity of Some New Derivatives of Aromatic Hydrocarbons I1.
Compounds Related to 1,2-Benzanthracene*t Charles E. Dunlap, M,D.,** and Shields Warren, M.D. (From the Laboratory o/ Pathology, Harvard Cancer Commission, and the Department.
The purpose of this investigation was to identify the substances mainly responsible for the carcinogenic effect of used engine oil from gasoline engines using topical application as a carcinogen-specific bioassay. This was performed by comparison of the tumorigenic effect of single fractions with th.
Vol. 88, No. 1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Pages COMPARATIVE REACTIVITIES OF DIOLEPOXIDE METABOLITES OF CARCINOGENIC HYDROCARBONS WITH OX VIRAL DNA W.
Hsu*t, E. Lin*, P. Fu tt, R. Harveytt, and S. Weiss*t s The Franklin. The text also ponders on the extrinsic factors in the induction of tumors, including comparative carcinogenicity of hydrocarbons, metabolic fate of injected hydrocarbons, dosage and response to carcinogenic hydrocarbons, and polycyclic hydrocarbons.
The manuscript takes a look at the intrinsic factors in the induction of tumors. Recently a new methodology based on local density of state (LDOS) calculations using topological and semiempirical methods was proposed to identify the carcinogenic activity of polycyclic aromatic hydrocarbons (PAHs).
In this work we perform a comparative study of this methodology with principal component analysis (PCA) and neural networks (NN). Activated metabolites of carcinogenic hydrocarbons.
Accounts of Chemical Research14 (7), Synthesis and biological activity of some known and putative duloxetine metabolites. Bioorganic & Medicinal Chemistry Letters14 Comparative reactivities of diolepoxide metabolites of carcinogenic hydrocarbons with ØX viral DNA.
A comparative study between bay-region and nonbay-region diol epoxide (DE) derivatives of seventeen carcinogenic polycyclic aromatic hydrocarbons (PAHs) was carried out using the B3LYP/6–31G(d,p) level of density functional theory to understand the factors responsible for the increased carcinogenic activity of bay-region derivatives.
Molecular electrostatic potential. A quantitative structure-activity study for the carcinogenic activity of methylated polycyclic aromatic hydrocarbons is made on the basis of topological.
This book begins with a brief review of the early work on the mechanism of chemical carcinogenesis by polynuclear hydrocarbons, followed by a detailed survey of pertinent literature in the field.
The cytotoxic, mutagenic, and carcinogenic effects of arene oxides are analyzed, along with the solvolytic and nucleophilic reactions of benzo[a. Abstract. It seems likely that events leading to the induction of cancer by polycyclic aromatic hydrocarbons involve a number of steps.
However, the primary, initiating event appears to require the conversion of the carcinogens by metabolism into electrophiles that react with nucleophilic centres, such as those in nucleic acids, within the cells. System Upgrade on Tue, May 19th, at 2am (ET) During this period, E-commerce and registration of new users may not be available for up to 12 hours.
Carcinogenic Activity of Unsubstituted and Alkyl-substituted Benzanthracenes. 15 IARC Classifications of the Carcinogenicity of Several Individual PAHs. 23 Summary of Results of Tests for Genotoxicity and Carcinogenicity for the Polycyclic aromatic hydrocarbons (PAHs) are a class of widespread environmental carcinogens.
Most of our knowledge of their mechanisms of metabolic activation to DNA‐binding “ultimate carcinogenic” metabolites has come from analysis of the DNA interaction products formed by these highly reactive intermediates.
Some Halogenated Hydrocarbons IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume IARC. ISBN (Print Book) ISBN (PDF) Formats Print Book PDF.
Other languages No other languages. Contact Us. The threat to humans, animals, and plants life by pollution due to gas flare and oil and gas industrial activities cannot be overemphasized.
This study compared the hydrocarbons and heavy metals accumulation in cassava tubers harvested from four different locations in Rivers State. The study areas include Rukpoku, Rivers State University (RSU) farm, Eleme.
View Lancet Oncology summary as HTML or PDF French version of the Lancet Oncology summary (hosted by Centre Léon Bérard). This one-hundred-and-third volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of bitumens and bitumen emissions, and of some N- and S-heterocyclic polycyclic aromatic hydrocarbons.
settling. Some PAHs evaporate into the atmosphere from surface waters, but most stick to solid particles and settle to the bottoms of rivers or lakes. In soils, PAHs are most likely to stick tightly to particles.
Some PAHs evaporate from surface soils to air. Certain PAHs in soils also contaminate underground water.Chen J, Wang S, Hsieh D, Yang H and Lee H () Carcinogenic potencies of polycyclic aromatic hydrocarbons for back-door neighbors of restaurants with cooking emissions, Science of The Total Environment, /env,(), Online publication date: 1-Feb Halek et al.
() estimated that the annual number of lung cancer cases attributable to carcinogenic PAH compounds in was 58 persons per million. The BaP is the highest carcinogenic contributor, followed by DahA, Ind and BbF (Pufulete et al., ).
However, DahA was suggested as a new surrogate compound to measure the toxicity of.